Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Schwann cells develop from the neural crest in a well-defined sequence of events. This
involves the formation of the Schwann cell precursor and immature Schwann cells, followed …

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …

Peripheral nerve injury can lead to great morbidity in those afflicted, ranging from sensory
loss, motor loss, chronic pain, or a combination of deficits. Over time, research has …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

The cells of the neural crest, often referred to as neural crest stem cells, give rise to a
number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves …

Myelin is essential to nervous system function, playing roles in saltatory conduction and
trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central …

The neural crest (NC) is an embryonic stem/progenitor cell population that generates a
diverse array of cell lineages, including peripheral neurons, myelinating Schwann cells, and …

Defining the unique molecular features of progenitors and their niche requires a genome-
wide, whole-tissue approach with cellular resolution. Here, we co-isolate embryonic hair …

Notch signaling is central to vertebrate development, and analysis of Notch has provided
important insights into pathogenetic mechanisms in the CNS and many other tissues …