Monkeypox virus (MPXV) is a DNA virus belonging to the Orthopoxvirus genus within the
Poxviridae family which can cause a zoonotic infection. The unexpected non-endemic …

Even if a virus successfully binds to a cell, defects in any of the downstream steps of the viral
life cycle can preclude the production of infectious virus particles. Such abortive infections …

Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine
deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic …

Eukaryotic innate immune systems use pattern recognition receptors to sense infection by
detecting pathogen-associated molecular patterns, which then triggers an immune …

Background The dynamics of viral shedding and the specific humoral response against
monkeypox virus (MPXV) have not been well characterized in patients across their disease …

Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of
mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to …

Cyclophilins (Cyps), characterized as peptidyl-prolyl cis-trans isomerases (PPIases), are
highly conserved and ubiquitous, playing a crucial role in protein folding and cellular …

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the
assembly and activation of innate immune-signaling complexes. In response to viral …

Vaccinia virus assembly in the cytoplasm of infected cells involves the formation of a
biconcave viral core inside the maturing viral particle. The boundary of the core is defined by …

Histone deacetylases (HDACs) regulate gene expression and innate immunity. Previously,
we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a …