Resistance to the insulin and elevated level of androgen: A major cause of polycystic ovary syndrome

H Ding, J Zhang, F Zhang, S Zhang, X Chen… - Frontiers in …, 2021 - frontiersin.org
PCOS has a wide range of negative impacts on women's health and is one of the most
frequent reproductive systemic endocrine disorders. PCOS has complex characteristics and …

Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth

J Rojas, M Chávez, L Olivar, M Rojas… - International journal …, 2014 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine‐metabolic disorder that
implies various severe consequences to female health, including alarming rates of infertility …

Genetic syndromes of severe insulin resistance

RK Semple, DB Savage, EK Cochran… - Endocrine …, 2011 - academic.oup.com
Insulin resistance is among the most prevalent endocrine derangements in the world, and it
is closely associated with major diseases of global reach including diabetes mellitus …

Acanthosis nigricans: a review

A Das, D Datta, M Kassir, U Wollina… - Journal of cosmetic …, 2020 - Wiley Online Library
Background Acanthosis nigricans (AN) is a cutaneous disorder characterized by symmetric
velvety hyperpigmented plaques on intertriginous areas like axilla, neck, inframammary, and …

High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease

H Kim, KE Westerman, K Smith, J Chiou, JB Cole… - Diabetologia, 2023 - Springer
Aims/hypothesis Type 2 diabetes is highly polygenic and influenced by multiple biological
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …

An approach to acanthosis nigricans

MM Phiske - Indian dermatology online journal, 2014 - journals.lww.com
Acanthosis nigricans (AN) is characterized by dark, coarse and thickened skin with a velvety
texture, being symmetrically distributed on the neck, the axillae, antecubital and popliteal …

De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy

N Mueller, T Sassa, S Morales-Gonzalez… - Journal of medical …, 2019 - jmg.bmj.com
Background Very long-chain fatty acids (VLCFAs) are essential for functioning of biological
membranes. ELOVL fatty acid elongase 1 catalyses elongation of saturated and …

Cutaneous findings and systemic associations in women with polycystic ovary syndrome

TH Schmidt, K Khanijow, MI Cedars… - JAMA …, 2016 - jamanetwork.com
Importance Understanding of the associations among cutaneous findings, systemic
abnormalities, and fulfillment of the diagnostic criteria in women suspected of having …

Cutaneous manifestations of diabetes

A Hines, A Alavi, MDP Davis - Medical Clinics, 2021 - medical.theclinics.com
Diabetes mellitus (DM) is a significant worldwide health concern with an estimated global
prevalence of 9.3% in 2019. 1 Global incidence has more than doubled since 1990 and is …

Skin manifestations of insulin resistance: from a biochemical stance to a clinical diagnosis and management

G González-Saldivar, R Rodríguez-Gutiérrez… - Dermatology and …, 2017 - Springer
Abstract Worldwide, more than 1.9 billion adults are overweight, and around 600 million
people suffer from obesity. Similarly,~ 382 million individuals live with diabetes, and 40 …