Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its
effect has been well established in reducing the frequency of apnea, intermittent hypoxemia …

The incidence of preterm birth is increasing, leading to a growing population with potential
long-term pulmonary complications. Apnoea of prematurity (AOP) is one of the major …

Caffeine is the most widely used drug by both adults and children worldwide due to its ability
to promote alertness and elevate moods. It is effective in the management of apnea of …

The objective of this study was to develop a population model of the pharmacokinetics (PK)
of caffeine after orogastric or intravenous administration to extremely premature neonates …

Infants who are born prematurely are at significant risk of apnoea. In addition to the short-
term consequences such as hypoxia, apnoea of prematurity has been associated with long …

Caffeine is a silver bullet in neonatology. This ubiquitous trimethylxanthine, pervasively used
in the human diet and beverages, significantly impacts on major acute neonatal morbidities …

Caffeine citrate is the drug of choice for the pharmacological treatment of apnea of
prematurity. Factors such as maturity and genetic variation contribute to the interindividual …

Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more
than 80% of neonates with a birth weight less than 1,000 g. Methylxanthine therapies …

Apnea of prematurity (AOP) is a common and pervasive problem in very low birth weight
infants. Methylxanthines were reported> 40 years ago to be an effective therapy and, by the …

Caffeine is commonly prescribed in the NICU to treat apnea of prematurity. This review is an
update based on current knowledge of the mechanisms of action, pharmacologic properties …