In the past decade substantial progress has been made in understanding the organization
and biological activity of amphotericin B (AmB) in the presence of sterols in lipid …

Amphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the
clinic for several decades. Clinical applications of AmB, however, are limited by its …

For over 50 years, amphotericin has remained the powerful but highly toxic last line of
defense in treating life-threatening fungal infections in humans with minimal development of …

Amphotericin B (AmB) is a prototypical small molecule natural product that can form ion
channels in living eukaryotic cells and has remained refractory to microbial resistance …

Amphotericin B, an antifungal drug with a long history of use, forms fungicidal ion-permeable
channels across cell membranes. Using solid-state nuclear magnetic resonance …

Amphotericin B is the archetype for small molecules that form transmembrane ion channels.
However, despite extensive study for more than five decades, even the most basic features …

Sterol molecules are essential for maintaining the proper structure and function of eukaryotic
cell membranes. The influence of cholesterol (the principal sterol of higher animals) on the …

The incidence of resistant fungal pathogens has been increasing, especially in immuno-
compromised people. As such, considerable research has been focused on discovering anti …

Amphotericin B (AmB) is a clinically vital antimycotic but is limited by its severe toxicity.
Binding ergosterol, independent of channel formation, is the primary mechanism by which …

Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening
fungal infections. Two models have been proposed to illustrate AmB assembly in the cell …