Single B cell technologies for monoclonal antibody discovery
A Pedrioli, A Oxenius - Trends in immunology, 2021 - cell.com
Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells
derived from different hosts, which are notably short-lived in ex vivo culture conditions and …
derived from different hosts, which are notably short-lived in ex vivo culture conditions and …
Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …
are tremendous, the design and discovery of new candidates remain a time and cost …
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical
interventions against COVID-19 disease. However, their common genetic and biologic …
interventions against COVID-19 disease. However, their common genetic and biologic …
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
R Rappuoli, MJ Bottomley, U D'Oro, O Finco… - Journal of Experimental …, 2016 - rupress.org
Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Global research to combat the COVID-19 pandemic has led to the isolation and
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors
MSA Gilman, CA Castellanos, M Chen… - Science …, 2016 - science.org
Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in young
children and the elderly. There are currently no licensed RSV vaccines, and passive …
children and the elderly. There are currently no licensed RSV vaccines, and passive …
Systems analysis reveals high genetic and antigen-driven predetermination of antibody repertoires throughout B cell development
Antibody repertoire diversity and plasticity is crucial for broad protective immunity.
Repertoires change in size and diversity across multiple B cell developmental stages and in …
Repertoires change in size and diversity across multiple B cell developmental stages and in …
A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status
Background Lymphocyte receptor repertoires are continually shaped throughout the lifetime
of an individual in response to environmental and pathogenic exposure. Thus, they may …
of an individual in response to environmental and pathogenic exposure. Thus, they may …
The evolutionary and functional significance of germline immunoglobulin gene variation
The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …