A clear picture of the dynamic relationship between the host immune system and cancer is
emerging as the cells and molecules that participate in naturally occurring antitumour …

Abstract Type I interferons (IFN-I) are well-known inducers of tumor cell apoptosis and
antiangiogenesis via signaling through a common receptor interferon alpha receptor …

The airway epithelium represents the first point of contact for inhaled foreign organisms. The
protective arsenal of the airway epithelium is provided in the form of physical barriers and a …

Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

Before they infect red blood cells and cause malaria, Plasmodium parasites undergo an
obligate and clinically silent expansion phase in the liver that is supposedly undetected by …

Type I Interferons (IFNs) are hallmark cytokines produced in immune responses to all
classes of pathogens. Type I IFNs can influence dendritic cell (DC) activation, maturation …

Interferons (IFNs) are cytokines that are important for immune responses, particularly to
intracellular pathogens. They are divided into two structurally and functionally distinct types …

Regulated by histone acetyltransferases and deacetylases (HDACs), histone acetylation is a
key epigenetic mechanism controlling chromatin structure, DNA accessibility, and gene …

Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

Dendritic cells (DC) produce interleukin-12 (IL-12) in response to Toll-like receptor (TLR)
activation. Two major TLR signaling pathways participate in the response to pathogens: the …