Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …

E-cadherin is a key component of the adherens junctions that are integral in cell adhesion
and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells …

E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Junctional structures maintain the integrity of the endothelium. Recent studies have shown
that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals …

Abstract In 1977, Mason and Williams developed the concept of the alveolar epithelial type II
(AE2) cell as a defender of the alveolus. It is well known that AE2 cells synthesise, secrete …

The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the
extracellular matrix to permit normal remodeling and contribute to pathological tissue …