The discovery of giant viruses, with capsids as large as some bacteria, megabase-range
genomes and a variety of traits typically found only in cellular organisms, was one of the …

Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their
large genomes into viral capsids is mostly unknown. The major capsid protein and the …

Following the discovery of Acanthamoeba polyphaga mimivirus, diverse giant viruses have
been isolated. However, only a small fraction of these isolates have been completely …

The organization of DNA into nucleosomes is a ubiquitous and ancestral feature that was
once thought to be exclusive to the eukaryotic domain of life. Intriguingly, several …

Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form
superhelical structures around which DNA is wrapped. Recent studies have shown that …

Nucleosomes are DNA–protein complexes composed of histone proteins that form the basis
of eukaryotic chromatin. The nucleosome was a key innovation during eukaryotic evolution …

Common throughout life is the need to compact and organize the genome. Possible
mechanisms involved in this process include supercoiling, phase separation, charge …

Nucleosomes are a core-component of eukaryotic nuclei, forming the structural basis of
chromatin and co-ordinating processes from gene expression to chromosome segregation …

Histone mimicry (HM) refers to the presence of short linear motifs in viral proteins that mimic
critical regions of host histone proteins. These motifs have the potential to interfere with host …

Viruses use multiple strategies to successfully generate progeny and overcome host
defenses. In recent years, it has become increasingly evident that epigenetic mechanisms of …