Following their activation and expansion in response to foreign threats, many T cells are
retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ …

The unprecedented pandemic of coronavirus disease 2019 (COVID-19) demands effective
treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The …

Complex interactions between host immunity and the microbiome regulate norovirus
infection. However, the mechanism of host immune promotion of enteric virus infection …

The intestinal microbiota comprises diverse fungal and viral components, in addition to
bacteria. These microbes interact with the immune system and affect human physiology …

Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among
children in developing countries. The host response to enteric viruses occurs primarily within …

Although tuft cells were discovered over 60 years ago, their functions have long been
enigmatic, especially in human health. Nonetheless, tuft cells have recently emerged as key …

Tissue-resident memory T cells (TRM cells) are a population of immune cells that reside in
the lymphoid and non-lymphoid organs without recirculation through the blood. These …

Although lymphocytes are known to circulate throughout lymphoid tissues and blood, they
also establish residency in nonlymphoid organs, most prominently in barrier tissues, such as …

The composition of the human microbiome is considered a major source of interindividual
variation in immunity and, by extension, susceptibility to diseases. Intestinal bacteria have …

Enteric viruses display intricate adaptations to the host mucosal immune system to
successfully reproduce in the gastrointestinal tract and cause maladies ranging from …