The discovery of Toxoplasma gondii independently by Nicolle and Manceaux (1908) and
Splendore (1908) was to open a" Pandora's Box" that has led research on this parasite into …

Abstract According to World Health Organization estimates, infectious organisms are
responsible for approximately one in four deaths worldwide. Animal models play an …

NF-κB is an integral component of the immune response to Toxoplasma gondii. Although
evidence exists that T. gondii can directly modulate the NF-κB pathway, the parasite-derived …

The obligate intracellular parasite Toxoplasma gondii is able to infect nearly all nucleated
cell types of warm-blooded animals. This is achieved through the injection of hundreds of …

Identification of regulators of Toxoplasma gondii bradyzoite development and cyst formation
is the most direct way to address the importance of parasite development in long-term …

The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host
cell that manipulate the immune response allowing it to establish a chronic infection …

Summary European and North American strains of the parasite Toxoplasma gondii belong
to three distinct clonal lineages, type I, type II, and type III, which differ in virulence …

IFN-γ activates cells to restrict intracellular pathogens by upregulating cellular effectors
including the p65 family of guanylate-binding proteins (GBPs). Here we test the role of Gbp1 …

Secretory polymorphic serine/threonine kinases control pathogenesis of Toxoplasma gondii
in the mouse. Genetic studies show that the pseudokinase ROP5 is essential for acute …

Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …