Heterogeneous ribonucleoproteins (hnRNPs) are RNA binding molecules that are involved
in key processes such as RNA splicing and transcription. One such hnRNP protein, hnRNP …

Splicing is a crucial process in gene expression in higher organisms because: 1) most
vertebrate genes contain introns; and 2) alternative splicing is primarily responsible for …

Background Alport syndrome is an inherited disorder characterized by progressive renal
disease, variable sensorineural hearing loss, and ocular abnormalities. Although many …

LIST OF ABBREVIATIONS µg microgram µl microliter µM micromolar aa amino acid AAV
adeno-associated virus ABCA4 human ATP-binding cassette transporter A4 gene ABCR …

We construct and analyse a computational model that predicts the outcome of alternative
splicing by recognizing features in RNA sequences. The computational model can be …

Any individual's human genome will have several million deviations from the consensus
human genome sequence. Understanding whether these mutations are relevant or …