Quantitative stimulated Raman scattering microscopy: promises and pitfalls

B Manifold, D Fu - Annual Review of Analytical Chemistry, 2022 - annualreviews.org
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a
powerful chemical imaging tool that shows promise in numerous biological and biomedical …

Spectroscopic techniques for monitoring stem cell and organoid proliferation in 3D environments for therapeutic development

W Mao, HTD Bui, W Cho, HS Yoo - Advanced Drug Delivery Reviews, 2023 - Elsevier
Spectroscopic techniques for monitoring stem cell and organoid proliferation have gained
significant attention in therapeutic development. Spectroscopic techniques such as …

Millimetre-deep micrometre-resolution vibrational imaging by shortwave infrared photothermal microscopy

H Ni, Y Yuan, M Li, Y Zhu, X Ge, J Yin, CP Dessai… - Nature …, 2024 - nature.com
Deep tissue chemical imaging has a vital role in biological and medical applications.
Current approaches suffer from water absorption and tissue scattering, which limits imaging …

Bringing vibrational imaging to chemical biology with molecular probes

J Du, H Wang, L Wei - 2022 - ACS Publications
As an emerging optical imaging modality, stimulated Raman scattering (SRS) microscopy
provides invaluable opportunities for chemical biology studies using its rich chemical …

Protein and lipid mass concentration measurement in tissues by stimulated Raman scattering microscopy

S Oh, CH Lee, W Yang, A Li… - Proceedings of the …, 2022 - National Acad Sciences
Cell mass and chemical composition are important aggregate cellular properties that are
especially relevant to physiological processes, such as growth control and tissue …

[HTML][HTML] Advances in stimulated Raman scattering imaging for tissues and animals

L Shi, AA Fung, A Zhou - Quantitative imaging in medicine and …, 2021 - ncbi.nlm.nih.gov
Stimulated Raman scattering (SRS) microscopy has emerged in the last decade as a
powerful optical imaging technology with high chemical selectivity, speed, and subcellular …

Practical considerations for quantitative and reproducible measurements with stimulated Raman scattering microscopy

D Tsikritsis, EJ Legge, NA Belsey - Analyst, 2022 - pubs.rsc.org
Stimulated Raman scattering (SRS) microscopy provides rapid label-free 3D chemical
imaging with wide-ranging applications including histology, pharmacokinetic studies, and …

Measuring Drug Response with Single-Cell Growth Rate Quantification

FX Xu, R Wu, K Hu, D Fu - Analytical Chemistry, 2023 - ACS Publications
Intratumoral heterogeneity is a substantial cause of drug resistance development during
chemotherapy or other drug treatments for cancer. Therefore, monitoring and measuring cell …

Self-stacked small molecules for ultrasensitive, substrate-free Raman imaging in vivo

S Gao, Y Zhang, K Cui, S Zhang, Y Qiu, Y Liao… - Nature …, 2024 - nature.com
Raman spectroscopy using surface-enhanced Raman scattering (SERS) nanoprobes
represents an ultrasensitive and high-precision technique for in vivo imaging. Clinical …

Dissecting lipid droplet biology with coherent Raman scattering microscopy

T Chen, A Yavuz, MC Wang - Journal of Cell Science, 2022 - journals.biologists.com
Lipid droplets (LDs) are lipid-rich organelles universally found in most cells. They serve as a
key energy reservoir, actively participate in signal transduction and dynamically …