The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

Background By regulating target genes, microRNAs play essential roles in carcinogenesis
and drug resistance in human pancreatic ductal adenocarcinoma (PDAC). Previous studies …

Abstract The REarranged during Transfection (RET) receptor tyrosine kinase plays a crucial
role in the development of various anatomical structures during embryogenesis and it is …

Purpose Resistance to endocrine therapy is the primary cause of treatment failure and death
in patients with ER-positive (ER+)/luminal breast cancer. Expression and activation of the …

The vascular endothelial growth factor receptor (VEGFR) network contributes to breast
cancer pathogenesis and progression. Anlotinib is a highly potent multi‑target tyrosine …

Purpose: Recent findings suggest that combination treatment with antiestrogen and anti-
RET may offer a novel treatment strategy in a subset of patients with breast cancer. We …

Transcripts derived from the PTEN pseudogene (PTENP1) function as decoys to adsorb
miRNAs targeting the PTEN tumor suppressor for degradation, and PTENP1 upregulation is …

Expression of TFAP2C in luminal breast cancer is associated with reduced survival and
hormone resistance, partially explained through regulation of RET. TFAP2C also regulates …

The expression of carbonic anhydrase XII (CA12) is associated with the expression of
estrogen receptor alpha (ERα) in breast cancer and is linked to a good prognosis with a …

A significant proportion of estrogen receptor‐positive (ER+) breast cancer (BC) initially
responds to endocrine therapy but eventually evolves into therapy‐resistant BC …