Progress on the roles of MEF2C in neuropsychiatric diseases

Z Zhang, Y Zhao - Molecular brain, 2022 - Springer
Abstract Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-
BOX family, is involved in embryonic brain development, neuronal formation and …

Emerging roles for MEF2 in brain development and mental disorders

A Assali, AJ Harrington, CW Cowan - Current opinion in neurobiology, 2019 - Elsevier
Highlights•MEF2s control gene expression in the developing and adult brain.•MEF2s
regulate synaptic plasticity during critical periods of brain development.•Sensory …

A technology-agnostic long-read analysis pipeline for transcriptome discovery and quantification

D Wyman, G Balderrama-Gutierrez, F Reese, S Jiang… - Biorxiv, 2019 - biorxiv.org
Alternative splicing is widely acknowledged to be a crucial regulator of gene expression and
is a key contributor to both normal developmental processes and disease states. While cost …

Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development

L Shi, X Luo, J Jiang, Y Chen, C Liu, T Hu… - National Science …, 2019 - academic.oup.com
Brain size and cognitive skills are the most dramatically changed traits in humans during
evolution and yet the genetic mechanisms underlying these human-specific changes remain …

Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses

L Solé‐Boldo, G Raddatz, J Gutekunst… - Molecular systems …, 2022 - embopress.org
Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations,
posing a significant medical and economic burden to health systems. KC originate in the …

Decreased MEF2A expression regulated by its enhancer methylation inhibits autophagy and may play an important role in the progression of Alzheimer's disease

H Li, F Wang, X Guo, Y Jiang - Frontiers in neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid plaques
and neurofibrillary tangles which significantly affects people's life quality. Recently, AD has …

Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells

J Sun, Y Ruan, J Xu, P Shi, H Xu - Genes, 2023 - mdpi.com
Myocyte enhancer factor 2A (MEF2A) is a member of the myocyte enhancer factor 2 family.
MEF2A is widely distributed in various tissues and organs and participates in various …

[HTML][HTML] Myocyte enhancer factor 2A plays a central role in the regulatory networks of cellular physiopathology

B Liu, WC Ou, L Fang, CW Tian, Y Xiong - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Cell regulatory networks are the determinants of cellular homeostasis. Any alteration to
these networks results in the disturbance of cellular homeostasis and induces cells towards …

Analysis of differentially expressed genes in the dentate gyrus and anterior cingulate cortex in a mouse model of depression

Y Wei, K Qi, Y Yu, W Lu, W Xu… - BioMed Research …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a prevalent, chronic, and relapse‐prone psychiatric
disease. However, the intermediate molecules resulting from stress and neurological …

The role of MEF2 transcription factor family in neuronal survival and degeneration

M Lisek, O Przybyszewski, L Zylinska, F Guo… - International Journal of …, 2023 - mdpi.com
The family of myocyte enhancer factor 2 (MEF2) transcription factors comprises four highly
conserved members that play an important role in the nervous system. They appear in …