Tumour cells often display an active metabolic profile, leading to the intracellular
accumulation of reactive oxygen species. As a member of the peroxidase family …

One of the major challenges that remain in the fields of aging and lifespan determination
concerns the precise roles that reactive oxygen species (ROS) play in these processes …

Peroxiredoxins are important regulators of cellular peroxide metabolism. As antioxidants,
they restrict oxidation of other cell proteins, but as signaling molecules they can act as …

The excessive production of various reactive oxidant species over endogenous antioxidant
defense mechanisms leads to the development of a state of oxidative stress, with serious …

Three decades of research on the biochemistry of peroxynitrite (ONOOH/ONOO−) have
established that this stealthy oxidant is formed in biological systems, and that its main targets …

We have studied the reduction reactions of two cytosolic human peroxiredoxins (Prx) in their
disulfide form by three thioredoxins (Trx; two human and one bacterial), with the aim of better …

Mitochondria (mt) represent the vital hub of the molecular physiology of the cell, being
decision-makers in cell life/death and information signaling, including major redox …

Abstract Hydrogen peroxide (H 2 O 2), a natural metabolite commonly found in aerobic
organisms, plays a crucial role in numerous cellular signaling processes. One of the key …

Phospholipids containing oxidized esterified PUFA residues (OxPLs) are increasingly
recognized for multiple biological activities and causative involvement in disease …

Redox signaling from mitochondria (mt) to the cytosol and plasma membrane (PM) has been
scarcely reported, such as in the case of hypoxic cell adaptation or (2-oxo-) 2-keto …