The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …

Innate lymphoid cells (ILC) are a heterogeneous group of immune cells characterized by
lymphoid morphology and cytokine profile similar to T cells but which do not express clonally …

Innate lymphocytes are integral components of the cellular immune system that can
coordinate host defense against a multitude of challenges and trigger immunopathology …

Malignancy can be suppressed by the immune system. However, the classes of
immunosurveillance responses and their mode of tumor sensing remain incompletely …

Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of
cancer progression. Established tumors contain phenotypically distinct, tumor-specific …

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are populations of non-T,
non-B lymphocytes in peripheral tissues. Although NK and ILC1 subsets have been …

Innate lymphoid cells (ILCs) are a group of innate lymphocytes that do not express RAG-
dependent rearranged antigen-specific cell surface receptors. ILCs are classified into five …

Identification of type 1 innate lymphoid cells (ILC1s) has been problematic. The transcription
factor Hobit encoded by Zfp683 has been proposed as a major driver of ILC1 programs …

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) require signal transducer
and activator of transcription 4 (STAT4) to elicit rapid effector responses and protect against …

The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a
previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to …