SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine
proteases, one of which is cathepsin G. As an acute-phase protein secreted into the plasma …

Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …

The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance
human-to-human transmission,. Although much effort has focused on the characterization of …

Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected
individuals. Controlling the excessive production of pro-inflammatory cytokines and …

Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

Coronavirus has brought about three massive outbreaks in the past two decades. Each step
of its life cycle invariably depends on the interactions among virus and host molecules. The …

The 2019 outbreak of SARS-CoV-2 has caused a major worldwide health crisis with high
rates of morbidity and death. Interestingly, it has also been linked to cancer, which begs the …

We present a bioprinted three-layered airway model with a physiologically relevant
microstructure for the study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Recent studies suggest the enhancement of liver injury in COVID-19 patients infected with
Hepatitis C virus (HCV). Hepatocytes express low levels of angiotensin-converting enzyme 2 …

SARS-CoV-2 is the causative agent of COVID-19, which has greatly affected human health
since it first emerged. Defining the human factors and biomarkers that differentiate severe …