Although inflammatory cytokines induced by infection or vaccination with adjuvants have
long been known to stimulate optimal antigen-presenting cell function, recent evidence …

The field of dendritic cell (DC) biology is robust, with several new approaches to analyze
their role in vivo and many newly recognized functions in the control of immunity and …

Efficient boosting of memory T-cell numbers to protective levels generally requires a
relatively long interval between immunizations. Decreasing this interval could be crucial in …

Viruses are leading causes of severe acute lower respiratory infections (LRIs). These
infections evoke incomplete immunity, as individuals can be repeatedly reinfected …

In response to infection, antigen‐specific CD8+ T cells undergo massive expansion in
numbers, acquire effector mechanisms, and disseminate throughout the body. The …

Once feared as a deadly intracellular bacterium with the extraordinary capacity to survive a
wide array of arduous external stressors, Listeria monocytogenes is increasingly recognized …

Substantial CD8+ T cell responses are generated after infection of mice with recombinant
Listeria monocytogenes strains expressing a model epitope (lymphocytic choriomeningitis …

Infection with Listeria monocytogenes elicits expansion in numbers of Ag-specific CD8+ T
cells, which then undergo programmed contraction. The remaining cells undergo further …

Perforin-mediated cytotoxicity is essential for clearance of primary LCMV infection. BALB/c-
perforin-deficient (PKO) mice survived LCMV infection by deleting NP 118-specific CD8+ T …

Abstract Naive Ag-specific CD8+ T cells expand, contract, and become memory cells after
infection and/or vaccination. Memory CD8+ T cells provide faster, more effective secondary …