Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance

J Feng, Y Zheng, W Ma, A Ihsan, H Hao… - Pharmacology & …, 2023 - Elsevier
The rise of antibiotic resistance and the decrease in the discovery of new antibiotics have
caused a global health crisis. Of particular concern is the fact that despite efforts to develop …

Machine learning in onco-pharmacogenomics: A path to precision medicine with many challenges

A Mondello, M Dal Bo, G Toffoli… - Frontiers in Pharmacology, 2024 - frontiersin.org
Over the past two decades, Next-Generation Sequencing (NGS) has revolutionized the
approach to cancer research. Applications of NGS include the identification of tumor specific …

Advanced network pharmacology study reveals multi-pathway and multi-gene regulatory molecular mechanism of Bacopa monnieri in liver cancer based on data …

M Sadaqat, M Qasim, MT ul Qamar, MS Masoud… - Computers in biology …, 2023 - Elsevier
Liver cancer is a malignant tumor that grows on the surface or inside the liver. The leading
cause is a viral infection with hepatitis B or C virus. Natural products and their structural …

[HTML][HTML] Therapeutic effects and mechanism of action of lavender essential oil on atopic dermatitis by modulating the STAT3/RORγt pathway

J Duan, J Li, Y Wang, P Zhou, X Wang, N Xia… - Arabian Journal of …, 2024 - Elsevier
Objectives Atopic dermatitis (AD) is a common skin disorder characterized by skin
inflammation caused by an imbalance in the immune response. The efficacy of lavender …

From seeds to survival rates: investigating Linum usitatissimum's potential against ovarian cancer through network pharmacology

MM Islam, N Sreeharsha, FM Alshabrmi… - Frontiers in …, 2023 - frontiersin.org
Ovarian cancer is a malignant tumor that primarily forms in the ovaries. It often goes
undetected until it has spread to the pelvis and abdomen, making it more challenging to treat …

Unveiling the multi-target compounds of Rhazya stricta: discovery and inhibition of novel target genes for the treatment of clear cell renal cell carcinoma

A Rehman, I Fatima, Y Wang, J Tong, F Noor… - Computers in Biology …, 2023 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is a prevalent kidney malignancy with a pressing
need for innovative therapeutic strategies. In this context, emerging research has focused on …

Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in …

HG Jo, CY Baek, HS Song, D Lee - International Journal of Molecular …, 2024 - mdpi.com
Osteoarthritis is the most common type of arthritis, characterized by joint pain and a decline
in physiological function. Scutellaria baicalensis Georgi (SB) is potentially effective against …

Multi-perspective neural network for dual drug repurposing in Alzheimer's disease

L Zhao, Z Li, G Chen, Y Yin, CYC Chen - Knowledge-Based Systems, 2024 - Elsevier
In the field of drug discovery, the large-scale prediction of drug-target affinity (DTA) is
essential. Despite recent advancements in deep learning enhancing DTA prediction, many …

Medicine for chronic atrophic gastritis: a systematic review, meta-and network pharmacology analysis

J Weng, X Wu, P Shao, X Liu, C Wang - Annals of Medicine, 2023 - Taylor & Francis
Purpose The aim of this study is to determine the effectiveness and reliability of adding
traditional Chinese medicine (TCM) in the clinical intervention and explore mechanisms of …

Network pharmacology and molecular dynamic simulation integrated strategy for the screening of active components and mechanisms of phytochemicals from Datura …

MA Alamri, M Tahir ul Qamar - Journal of Biomolecular Structure …, 2024 - Taylor & Francis
Alzheimer's disease (AD) ranks as the most prevalent neurodegenerative disorder with
dementia and it accounts for more than 70% of all cases. Despite extensive reporting on the …