More than just an enzyme: Dipeptidyl peptidase-4 (DPP-4) and its association with diabetic kidney remodelling

S Gupta, U Sen - Pharmacological research, 2019 - Elsevier
Purpose of the review This review article discusses recent advances in the mechanism of
dipeptidyl peptidase-4 (DPP-4) actions in renal diseases, especially diabetic kidney fibrosis …

Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

TK Nemoto, Y Ohara Nemoto - Molecular oral microbiology, 2021 - Wiley Online Library
Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic
microorganism that solely utilizes nutritional amino acids as its energy source and cellular …

Expanded substrate specificity supported by P1′ and P2′ residues enables bacterial dipeptidyl-peptidase 7 to degrade bioactive peptides

Y Ohara-Nemoto, Y Shimoyama, T Ono… - Journal of Biological …, 2022 - ASBMB
Dipeptide production from extracellular proteins is crucial for Porphyromonas gingivalis, a
pathogen related to chronic periodontitis, because its energy production is entirely …

Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7 and DPP11 in human oral microbiota—potent biomarkers indicating presence of periodontopathic bacteria

Y Ohara-Nemoto, Y Shimoyama… - FEMS Microbiology …, 2018 - academic.oup.com
Abstract Dipeptidyl peptidase (DPP) 4, DPP5, DPP7 and DPP11, expressed in the
periplasmic space, are crucial for energy production for Porphyromonas gingivalis, an …

Capnocytophaga canimorsus infection led to progressively fatal septic shock in an immunocompetent patient

R Nakayama, S Miyamoto, T Tawara… - Acute medicine & …, 2022 - Wiley Online Library
Background Capnocytophaga canimorsus infection is rare, with a high fatality rate; however,
there are few cases of death with a rapid course. This study reports a progressively fatal …

[HTML][HTML] Purpura fulminans secondary to Capnocytophaga canimorsus bacteraemia following a dog bite: A case report and review of literature

K Killington, N Lee, R Asher, O Farrant… - Access …, 2023 - microbiologyresearch.org
Introduction. Infection due to Capnocytophaga canimorsus may result in a wide variety of
clinical presentations. We present a case of life-threatening Capnocytophaga canimorsus …

Dipotassium glycyrrhizate prevents oral dysbiosis caused by Porphyromonas gingivalis in an in vitro saliva-derived polymicrobial biofilm model

K Ohara, K Tomiyama, T Okuda, K Tsutsumi… - Journal of Oral …, 2024 - Elsevier
Objectives Oral microbiome dysbiosis prevention is important to avoid the onset and
progression of periodontal disease. Dipotassium glycyrrhizate (GK2) is a licorice root extract …

Establishment of potent and specific synthetic substrate for dipeptidyl-peptidase 7

TK Nemoto, T Ono, Y Ohara-Nemoto - Analytical biochemistry, 2018 - Elsevier
Abstract Bacterial dipeptidyl-peptidase (DPP) 7 liberates a dipeptide with a preference for
aliphatic and aromatic penultimate residues from the N-terminus. Although synthetic …

Identification of a new subtype of dipeptidyl peptidase 11 and a third group of the S46-family members specifically present in the genus Bacteroides

TK Nemoto, GA Bezerra, T Ono, H Nishimata… - Biochimie, 2018 - Elsevier
Peptidase family S46 consists of two types of dipeptidyl-peptidases (DPPs), DPP7 and
DPP11, which liberate dipeptides from the N-termini of polypeptides along with the …

Detection of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs with periodontal disease of Brazil

BS Nogueira, A de Cássia Martini… - Research, Society and …, 2021 - rsdjournal.org
Capnocytophaga canimorsus e Capnocytophaga cynodegmi são bacilos Gram-negativos
encontrados na microbiota oral de cães e gatos capazes de infectar humanos através de …