Microbial alcohol dehydrogenases: recent developments and applications in asymmetric synthesis

A Chadha, SK Padhi, S Stella… - Organic & …, 2024 - pubs.rsc.org
Alcohol dehydrogenases are a well-known group of enzymes in the class of
oxidoreductases that use electron transfer cofactors such as NAD (P)+/NAD (P) H for …

Efficient whole-cell biosynthesis of (S)-2-chloro-1-(3, 4-difluorophenyl)-ethanol from 2-chloro-1-(3, 4-difluorophenyl) ethanone in a sustainable reaction system

L Kong, B Fan, YC He - Molecular Catalysis, 2023 - Elsevier
Abstract (S)-2-Chloro-1-(3, 4-difluorophenyl)-ethanol [(S)-CFPL] is a key chiral intermediate
in the manufacture of Ticagrelor. In this study, deep eutectic solvent (DES) was used as the …

Stereochemistry in asymmetric reduction of bulky–bulky ketones by alcohol dehydrogenases

J Zhou, G Xu, Y Ni - ACS Catalysis, 2020 - ACS Publications
Biocatalyzed asymmetric reduction of ketones is one of the most cost-effective and
environmentally friendly approaches for preparing chiral alcohols. However, few natural …

The song remains the same. The lab bench dilemma of using shaken flasks in microbial biotransformation experiments

NS de Oliveira, GPL da Silva, O Furlan… - Biocatalysis and …, 2024 - Taylor & Francis
Microbial biotransformation is valuable for obtaining pharmaceutical, nutritional, and
cosmetical potential molecules. Basically, for its realization, only a parental molecule, a …

[图书][B] Studies in natural products chemistry

A Rahman - 2023 - books.google.com
Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

Efficient bioreduction of 1-(furan-2-yl) ethanone into enantiomerically pure drug precursor by Lactobacillus paracasei BD101

E Şahin - Molecular Catalysis, 2023 - Elsevier
Asymmetric bioreduction catalyzed by biocatalyst have shown considerable potential in the
preparation of chiral alcohols.(R)-1-(furan-2-yl) ethanol ((R)-2) can be used precursor in the …

Biocatalytic asymmetric synthesis of (R)‐1‐tetralol using Lactobacillus paracasei BD101

E Kalay, E Şahin - Chirality, 2021 - Wiley Online Library
Asymmetric bioreduction of ketones is a fundamental process in the production of organic
molecules. Compounds containing tetralone rings are found in the structure of many …

Regioselective asymmetric bioreduction of trans‐4‐phenylbut‐3‐en‐2‐one by whole‐cell of Weissella cibaria N9 biocatalyst

E Kalay, E Şahin - Chirality, 2021 - Wiley Online Library
There is a considerable interest in the asymmetric production of chiral allylic alcohols, the
main building blocks of many functional molecules. The asymmetric reduction of α, β …

Green synthesis of enantiopure (S)‐1‐(benzofuran‐2‐yl)ethanol by whole‐cell biocatalyst

E Şahin - Chirality, 2019 - Wiley Online Library
Optically active aromatic alcohols are valuable chiral building blocks of many natural
products and chiral drugs. Lactobacillus paracasei BD87E6, which was isolated from a …

Efficient bioreduction of cyclohexyl phenyl ketone by Leuconostoc pseudomesenteroides N13 biocatalyst using a distance-based design-focused optimization model

A Özdemir, E Şahin - Molecular Catalysis, 2022 - Elsevier
Whole-cell biocatalysts have been a popular method for the preparation of chiral alcohols.
Although asymmetric reduction of cyclohexyl (phenyl) methanone (1) by chemical catalysts …