The biological and pathological importance of mutual interactions between the nervous
system and cancer have become increasingly evident. The emerging field of cancer …

Cancer neuroscience has emerged as a burgeoning field for the investigation of cancer-
nervous system interactions. Perineural invasion (PNI) is defined as the presence of cancer …

Nerves are a component of the tumor microenvironment contributing to cancer progression,
but the role of cells from nerves in facilitating cancer invasion remains poorly understood …

Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer,
frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent …

Head and neck squamous cell carcinoma are highly innervated by peripheral sensory
neurons. Local neurotransmitter release (eg, calcitonin gene‐related peptide (CGRP)) from …

Emerging evidence suggests that the nervous system is involved in tumor development in
the periphery, however, the role of the central nervous system remains largely unknown …

Background Cancer stroma contains the neural compartment with specific components and
action. Neural microenvironment processing includes among others axonogenesis …

Although the pathogenic operations of cancer–nerve crosstalk (eg, neuritogenesis,
neoneurogensis, and perineural invasion—PNI) in the peripheral nervous system (PNS) …

The peripheral nervous system plays an important role in cancer progression. Studies in
multiple cancer types have shown that higher intratumoral nerve density is associated with …

Nerve infiltration in the tumor microenvironment is emerging as a promoter of cancer
progression that could be targeted in therapies, but the mechanisms initiating tumor …