The symptoms most commonly reported by patients affected by coronavirus disease (COVID-
19) include cough, fever, and shortness of breath. However, other major events usually …

Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

Background and Aims The presence of gastrointestinal symptoms and high levels of viral
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS …

Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are
therefore considered 'non-functional',–. As clinical behaviors vary widely and distant …

Abstract Purpose of Review To discuss the current understanding of “β cell identity” and
factors underlying altered identity of pancreatic β cells in diabetes, especially in humans …

Small-molecule inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) induce
human beta cells to proliferate, generating a labeling index of 1.5%–3%. Here, we …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …

Although it is well established that type 2 diabetes (T2D) is generally due to the progressive
loss of β-cell insulin secretion against a background of insulin resistance, the actual …

Glucagon-like peptide-1 receptor (GLP1R) agonists and dipeptidyl peptidase 4 inhibitors are
widely prescribed diabetes drugs due to their ability to stimulate insulin secretion from …