Unconventional T cell targets for cancer immunotherapy
DI Godfrey, J Le Nours, DM Andrews, AP Uldrich… - Immunity, 2018 - cell.com
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …
T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
The biology of NKT cells
A Bendelac, PB Savage, L Teyton - Annu. Rev. Immunol., 2007 - annualreviews.org
Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …
precursors through instructive signals emanating during TCR engagement by CD1d …
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
Y Kinjo, E Tupin, D Wu, M Fujio, R Garcia-Navarro… - Nature …, 2006 - nature.com
Natural killer T (NKT) cells recognize glycosphingolipids presented by CD1d molecules and
have been linked to defense against microbial infections. Previously defined foreign …
have been linked to defense against microbial infections. Previously defined foreign …
Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells
The nature of the antigens recognized by γδ T cells and their potential recognition of major
histocompatibility complex (MHC)-like molecules has remained unclear. Members of the …
histocompatibility complex (MHC)-like molecules has remained unclear. Members of the …
Tissue-specific roles of NKT cells in tumor immunity
M Terabe, JA Berzofsky - Frontiers in immunology, 2018 - frontiersin.org
NKT cells are an unusual population of T cells recognizing lipids presented by CD1d, a non-
classical class-I-like molecule, rather than peptides presented by conventional MHC …
classical class-I-like molecule, rather than peptides presented by conventional MHC …
The role of NKT cells in tumor immunity
M Terabe, JA Berzofsky - Advances in cancer research, 2008 - Elsevier
NKT cells are a relatively newly recognized member of the immune community, with
profound effects on the rest of the immune system despite their small numbers. They are true …
profound effects on the rest of the immune system despite their small numbers. They are true …
NKT cell activation mediates neutrophil IFN-γ production and renal ischemia-reperfusion injury
L Li, L Huang, SJ Sung, PI Lobo, MG Brown… - The Journal of …, 2007 - journals.aai.org
Previous work has shown that ischemia-reperfusion (IR) injury (IRI) is dependent on CD4+ T
cells from naive mice acting within 24 h. We hypothesize that NKT cells are key participants …
cells from naive mice acting within 24 h. We hypothesize that NKT cells are key participants …
Evolutionarily conserved amino acids that control TCR-MHC interaction
The rules for the conserved reaction of αβ T cell receptors (TCRs) with major
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …