Bioinspired Amino Acid Based Materials in Bionanotechnology: From Minimalistic Building Blocks and Assembly Mechanism to Applications

Y Wang, S Rencus-Lazar, H Zhou, Y Yin, X Jiang… - ACS …, 2023 - ACS Publications
Inspired by natural hierarchical self-assembly of proteins and peptides, amino acids, as the
basic building units, have been shown to self-assemble to form highly ordered structures …

The metabolostasis network and the cellular depository of aggregation‐prone metabolites

SA Levkovich, E Gazit… - Angewandte Chemie …, 2023 - Wiley Online Library
The vital role of metabolites across all branches of life and their involvement in various
disorders have been investigated for decades. Many metabolites are poorly soluble in water …

Branched-chain amino acid assembly into amyloid-like fibrils provides a new paradigm for maple syrup urine disease pathology

T Kreiser, I Sogolovsky-Bard, D Zaguri… - International Journal of …, 2023 - mdpi.com
Inborn error of metabolism disorders (IEMs) are a family of diseases resulting from single-
gene mutations that lead to the accumulation of metabolites that are usually toxic or interfere …

Interactions between Lipid Vesicle Membranes and Single Amino Acid Fibrils: Probable Origin of Specific Neurological Disorders

S Nandi, N Sarkar - Langmuir, 2024 - ACS Publications
Amyloid fibrils are known to be responsible for several neurological disorders, like
Alzheimer's disease (AD), Parkinson's disease (PD), etc. For decades, mostly proteins and …

A mechanoelastic glimpse on hyaluronan-coated extracellular vesicles

D Paul, A Paul, D Mukherjee, S Saroj… - The Journal of …, 2022 - ACS Publications
Cancer cells secrete extracellular vesicles (EVs) covered with a carbohydrate polymer,
hyaluronan (HA), linked to tumor malignancy. Herein, we have unravelled the contour …

A review on recent application of proton transfer photophysics of bipyridine-3, 3′-diol in organized assemblies

S Nandi, N Sarkar - Journal of Chemical Sciences, 2022 - Springer
The rich photophysics of the excited-state intramolecular proton transfer (ESIPT) process in
2, 2′-Bipyridine-3, 3′-diol (BP (OH) 2) system has interested a lot of researchers from both …

Amyloidogenic Propensity of Metabolites in the Uric Acid Pathway and Urea Cycle Critically Impacts the Etiology of Metabolic Disorders

M Patel, A Jaiswal, A Naseer, A Tripathi… - ACS Chemical …, 2024 - ACS Publications
Novel insights into the etiology of metabolic disorders have recently been uncovered
through the study of metabolite amyloids. In particular, inborn errors of metabolism (IEMs) …

Amyloid Mimicking Assemblies Formed by Glutamine, Glutamic Acid, and Aspartic Acid

A Jaiswal, M Patel, A Naseer, S Kumari… - ACS Chemical …, 2024 - ACS Publications
The aggregation of amino acids into amyloid-like structures is a critical phenomenon for
understanding the pathophysiology of various diseases, including inborn errors of …

The rise and fall of adenine clusters in the gas phase: a glimpse into crystal growth and nucleation

DS Oluwatoba, HA Safoah, TD Do - Analytical and Bioanalytical Chemistry, 2024 - Springer
The emergence of a crystal nucleus from disordered states is a critical and challenging
aspect of the crystallization process, primarily due to the extremely short length and …

A review on the self-assembly of phenylalanine as the hallmark of the neurological disorder phenylketonuria (PKU): Origin to therapeutic strategy

T Chowdhury, S Bardhan, R Maiti - Proceedings of the Indian National …, 2023 - Springer
One of the inborn errors of genetic metabolic disorder, Phenylketonuria (PKU) is a
neuropsychological disorder and is the result of the presence of an elevated concentration …