[HTML][HTML] Mechanistic Insights into the Mutational Landscape of the Main Protease/3CLPro and Its Impact on Long-Term COVID-19/SARS-CoV-2 Management

AGA Mushebenge, SC Ugbaja, NN Magwaza… - Future …, 2024 - mdpi.com
The main proteinase (Mpro), or 3CLpro, is a critical enzyme in the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) lifecycle and is responsible for breaking down and …

Enhanced detection and molecular modeling of adaptive mutations in SARS-CoV-2 coding and non-coding regions using the c/µ test

NJ Paradis, C Wu - Virus Evolution, 2024 - academic.oup.com
Accurately identifying mutations under beneficial selection in viral genomes is crucial for
understanding their molecular evolution and pathogenicity. Traditional methods like the …