One of the malignant tumors in women that has involved both developed and developing
countries is breast cancer. Similar to other types of tumors, breast cancer cells demonstrate …

RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …

Simple Summary Cancer is the leading cause of death worldwide, and the overall aging of
the population results in an increased risk of a cancer diagnosis during a person's lifetime …

Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial,
stromal, and immune) cell types constantly interact. Importantly, the abundance, localization …

Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in
their native microenvironment within the preserved architecture of a single tissue section. To …

The therapeutic benefits of immune checkpoint inhibitors (ICIs), which enable antitumor
immune responses, can be tempered by unwanted immune-related adverse events (irAEs) …

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

Radiotherapy serves as a crucial strategy in the treatment of colorectal cancer (CRC).
However, its efficacy is often hindered by the challenge of radiation resistance. Although the …

The extracellular matrix (ECM) plays critical roles in breast cancer development. Whether
ECM composition is regulated by the phosphorylation of eIF4E on serine 209, an event …