This review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic …

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited
syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated …

Genome-wide association studies (GWAS) using population-based designs have identified
many genetic loci associated with risk of a range of complex diseases including cancer; …

The development of colorectal cancer (CRC) can be influenced by genetic factors in both
familial cases and sporadic cases. Familial CRC has been associated with genetic changes …

The development of genome-wide massively parallel sequencing, ie, whole-genome and
whole-exome sequencing, and copy number approaches has raised high expectations for …

Background and aims Colorectal cancer (CRC) is the second most frequent cancer in
developed countries. Newfoundland has the highest incidence of CRC in Canada and the …

Background Estimates suggest that up to 30% of colorectal cancers (CRC) may develop due
to an increased genetic risk. The mean age at diagnosis for CRC is about 70 years. Time of …

It is proposed that a progressive series of mutations and epigenetic events leads to human
colorectal cancer (CRC) and metastasis. Furthermore, data from resequencing of the coding …

Background: Colorectal cancer (CRC) in densely affected families without Lynch Syndrome
may be due to mutations in undiscovered genetic loci. Familial linkage analyses have …

Survival rates from colorectal cancer (CRC) differ dramatically according to the stage of the
tumor at diagnosis, with survival rates of 90% for patients with stage I disease but only 49 …