Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …

A pathway from the natively unfolded microtubule-associated protein Tau to a highly
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …

Hereditary frontotemporal dementia associated with mutations in the microtubule‐
associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes …

Tau protein is involved in microtubule assembly and stabilization. Filamentous deposits
made of tau constitute a defining characteristic of several neurodegenerative diseases. The …

Tau deposition is found in a variety of neurodegenerative brain diseases. The identification
of tau mutations that cause familial dementia demonstrated that aberrant Tau alone could …

The abnormal deposition of proteins in and around neurons is a common pathological
feature of many neurodegenerative diseases. Among these pathological proteins, the …

Pathological accumulation of the microtubule-associated protein tau, in the form of
neurofibrillary tangles, is a major hallmark of Alzheimer's disease, the most prevalent …

Tau filaments with distinct morphologies and/or isoform compositions underlie a large
number of human neurodegenerative diseases. Their formation is important, because …