Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and
behavioral research. Physiological similarity to mammals, ease of genetic manipulations …

A great challenge in neuroscience is understanding how activity in the brain gives rise to
behavior. The zebrafish is an ideal vertebrate model to address this challenge, thanks to the …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

The postsynaptic apparatus of the skeletal neuromuscular junction, like that of other
synapses, contains a high-density patch of neurotransmitter receptors that is closely …

The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification
of the roles of specific genes and signaling pathways in development. The zebrafish …

The zebrafish is a leading model for studies of vertebrate development and genetics. Its
embryonic motor behaviors are easy to assess (eg for mutagenic screens), the embryos …

Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by a loss
of α motoneurons in the spinal cord. SMA is caused by low levels of the ubiquitously …

Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the
ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein …

Genetically encoded calcium indicators, such as cameleon, have offered the promise of
noninvasively monitoring activity of neurons, but no one has demonstrated whether these …

The ability of an animal to carry out its normal behavioral repertoire requires generation of
an enormous diversity of neurons and glia. The relative simplicity of the spinal cord makes …