Dog models of aging

A Ruple, E MacLean, N Snyder-Mackler… - Annual review of …, 2022 - annualreviews.org
As the most phenotypically diverse mammalian species that shares human environments
and access to sophisticated healthcare, domestic dogs have unique potential to inform our …

The companion dog as a model for human aging and mortality

JM Hoffman, KE Creevy, A Franks, DG O'Neill… - Aging cell, 2018 - Wiley Online Library
Around the world, human populations have experienced large increases in average lifespan
over the last 150 years, and while individuals are living longer, they are spending more …

[HTML][HTML] Assessment and management of declining physical function in aging dogs

BA McKenzie, FL Chen - Topics in companion animal medicine, 2022 - Elsevier
Aging is the leading cause of disability, disease, and death in adult dogs. One major
consequence of aging is diminishing physical function. For normal functioning, basic …

Demographic change across the lifespan of pet dogs and their impact on health status

LJ Wallis, D Szabó, B Erdélyi-Belle… - Frontiers in veterinary …, 2018 - frontiersin.org
Although dogs' life expectancies are six to twelve times shorter than that of humans, the
demographics (eg, living conditions) of dogs can still change considerably with aging …

Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds

BM Wiles, AM Llewellyn-Zaidi, KM Evans… - Canine genetics and …, 2017 - Springer
Background Pedigree or purebred dogs are often stated to have high prevalence of
disorders which are commonly assumed to be a consequence of inbreeding and selection …

Dogs don't die just in hot cars—exertional heat-related illness (Heatstroke) is a greater threat to UK dogs

EJ Hall, AJ Carter, DG O'Neill - Animals, 2020 - mdpi.com
Simple Summary Heat-related illness (often called heatstroke) is a potentially fatal condition
inflicted on dogs that will become more common as global temperatures rise. Understanding …

[HTML][HTML] Aging in cats: Owner observations and clinical finding in 206 mature cats at enrolment to the cat prospective aging and welfare study

N Dowgray, G Pinchbeck, K Eyre, V Biourge… - Frontiers in veterinary …, 2022 - frontiersin.org
Two hundred and six cats, aged between 7-10 years, from the North-west of the UK, were
enrolled in a cat ageing and welfare study to determine the frequency of age-related …

Evaluating instruments for assessing healthspan: a multi-center cross-sectional study on health-related quality of life (HRQL) and frailty in the companion dog

FL Chen, TV Ullal, JL Graves, ER Ratcliff, A Naka… - Geroscience, 2023 - Springer
Developing valid tools that assess key determinants of canine healthspan such as frailty and
health-related quality of life (HRQL) is essential to characterizing and understanding aging …

Morbidity and mortality in elderly dogs–a model for human aging

P Dias-Pereira - BMC veterinary research, 2022 - Springer
Over the last decades, canines have experienced a marked increase in their lifespan,
mirroring human populations. Several authors have pointed out the domestic dog as a …

Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs

AG Jimenez, J Winward, U Beattie, W Cipolli - PLoS One, 2018 - journals.plos.org
Among species, larger animals tend to live longer than smaller ones, however, the opposite
seems to be true for dogs—smaller dogs tend to live significantly longer than larger dogs …