SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

A Grifoni, J Sidney, R Vita, B Peters, S Crotty… - Cell host & …, 2021 - cell.com
Over the past year, numerous studies in the peer reviewed and preprint literature have
reported on the virological, epidemiological and clinical characteristics of the coronavirus …

The role of SARS-CoV-2 N protein in diagnosis and vaccination in the context of emerging variants: Present status and prospects

W Song, Z Fang, F Ma, J Li, Z Huang, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Despite many countries rapidly revising their strategies to prevent contagions, the number of
people infected with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Safety and efficacy of single-dose Ad26. COV2. S vaccine against Covid-19

J Sadoff, G Gray, A Vandebosch… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background The Ad26. COV2. S vaccine is a recombinant, replication-incompetent
human adenovirus type 26 vector encoding full-length severe acute respiratory syndrome …

The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection

CM Arieta, YJ Xie, DA Rothenberg, H Diao, D Harjanto… - Cell, 2023 - cell.com
T cell responses play an important role in protection against beta-coronavirus infections,
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …

Improved control of SARS-CoV-2 by treatment with a nucleocapsid-specific monoclonal antibody

T Dangi, S Sanchez, J Class, M Richner… - The Journal of …, 2022 - Am Soc Clin Investig
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the
main antigen in all approved COVID-19 vaccines and is also the only target for monoclonal …

[HTML][HTML] Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platform

AA Quadeer, SF Ahmed, MR McKay - Cell Reports Medicine, 2021 - cell.com
Knowledge of the epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) targeted by T cells in recovered (convalescent) individuals is important for understanding …

Multiple COVID-19 vaccine doses in CLL and MBL improve immune responses with progressive and high seroconversion

Y Shen, JA Freeman, J Holland, K Naidu… - Blood, The Journal …, 2022 - ashpublications.org
Patients with chronic lymphocytic leukemia (CLL) or monoclonal B-lymphocytosis (MBL)
have impaired response to COVID-19 vaccination. A total of 258 patients (215 with CLL and …

Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants

S Meyer, I Blaas, RC Bollineni, M Delic-Sarac, TT Tran… - Cell reports, 2023 - cell.com
The emergence of SARS-CoV-2 variants of concern (VOC) is driven by mutations that
mediate escape from neutralizing antibodies. There is also evidence that mutations can …

SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl accumulation in respiratory epithelium

L Chen, WJ Guan, ZE Qiu, JB Xu, X Bai… - … and Targeted Therapy, 2022 - nature.com
Abstract SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune
responses and cytokine storms. Intracellular Cl− is a crucial regulator of host defense …

[HTML][HTML] The HLA-II immunopeptidome of SARS-CoV-2

S Weingarten-Gabbay, DY Chen, S Sarkizova… - Cell reports, 2024 - cell.com
Targeted synthetic vaccines have the potential to transform our response to viral outbreaks,
yet the design of these vaccines requires a comprehensive knowledge of viral immunogens …