Respiratory viruses and virus-like particle vaccine development: how far have we advanced?

KB Chu, FS Quan - Viruses, 2023 - mdpi.com
With technological advancements enabling globalization, the intercontinental transmission
of pathogens has become much easier. Respiratory viruses are one such group of …

1Progress, applications, challenges and prospects of protein purification technology

M Du, Z Hou, L Liu, Y Xuan, X Chen, L Fan… - … in Bioengineering and …, 2022 - frontiersin.org
Protein is one of the most important biological macromolecules in life, which plays a vital
role in cell growth, development, movement, heredity, reproduction and other life activities …

Pseudotyping Improves the Yield of Functional SARS-CoV-2 Virus-like Particles (VLPs) as Tools for Vaccine and Therapeutic Development

AJ Zak, T Hoang, CM Yee, SM Rizvi, P Prabhu… - International Journal of …, 2023 - mdpi.com
Virus-like particles (VLPs) have been proposed as an attractive tool in SARS-CoV-2 vaccine
development, both as (1) a vaccine candidate with high immunogenicity and low …

A vaccine of SARS-CoV-2 S protein RBD induces protective immunity

Q Qu, P Hao, W Xu, L Li, Y Jiang, Z Xu, J Chen… - International Journal of …, 2022 - mdpi.com
The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has posed great threat to the world in many aspects. There is an urgent requirement for an …

Virus-like particles vaccines based on glycoprotein E0 and E2 of bovine viral diarrhea virus induce humoral responses

N Yang, J Zhang, M Xu, J Yi, Z Wang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Bovine viral diarrhea/mucosal disease (BVD/MD) is a viral infectious disease that seriously
endangers the health of cattle herds and brings serious economic losses to the global cattle …

Dimming the corona: studying SARS-coronavirus-2 at reduced biocontainment level using replicons and virus-like particles

G Neilsen, AM Mathew, JM Castro, WM McFadden… - Mbio, 2024 - journals.asm.org
The coronavirus-induced disease 19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) infections, has had a devastating impact …

Antibiotics daptomycin interacts with S protein of SARS-CoV-2 to promote cell invasion of Omicron (B1. 1.529) pseudovirus

X Cao, L Huang, M Tang, Y Liang, X Liu, H Hou… - Virulence, 2024 - Taylor & Francis
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed
enormous challenges to global public health. The use of antibiotics has greatly increased …

The Papain-like Protease Domain of Severe Acute Respiratory Syndrome Coronavirus 2 Conjugated with Human Beta-Defensin 2 and Co1 Induces Mucosal and …

BH Cho, J Kim, YS Jang - Vaccines, 2024 - mdpi.com
Most of the licensed vaccines against SARS-CoV-2 target spike proteins to induce viral
neutralizing antibodies. However, currently prevalent SARS-CoV-2 variants contain many …

Challenges and Opportunities in the Process Development of Chimeric Vaccines

S Chauhan, YP Khasa - Vaccines, 2023 - mdpi.com
Vaccines are integral to human life to protect them from life-threatening diseases. However,
conventional vaccines often suffer limitations like inefficiency, safety concerns, unavailability …