Current state-of-the-art and unresolved problems in using human induced pluripotent stem cell-derived dopamine neurons for parkinson's disease drug development
SA Antonov, EV Novosadova - International Journal of Molecular …, 2021 - mdpi.com
Human induced pluripotent stem (iPS) cells have the potential to give rise to a new era in
Parkinson's disease (PD) research. As a unique source of midbrain dopaminergic (DA) …
Parkinson's disease (PD) research. As a unique source of midbrain dopaminergic (DA) …
A selective, hydrogel‐based prodrug delivery system efficiently activates a suicide gene to remove undifferentiated human stem cells within neural grafts
The directed differentiation of human pluripotent stem cells (hPSCs) into defined populations
has advanced regenerative medicine, especially for Parkinson's disease where clinical trials …
has advanced regenerative medicine, especially for Parkinson's disease where clinical trials …
Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
IR de Luzy, KCL Law, N Moriarty, CPJ Hunt… - Nature …, 2021 - nature.com
Despite advancements in human pluripotent stem cells (hPSCs) differentiation protocols to
generate appropriate neuronal progenitors suitable for transplantation in Parkinson's …
generate appropriate neuronal progenitors suitable for transplantation in Parkinson's …
IAP-based cell sorting results in homogeneous transplantable dopaminergic precursor cells derived from human pluripotent stem cells
D Lehnen, S Barral, T Cardoso, S Grealish, A Heuer… - Stem Cell Reports, 2017 - cell.com
Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA)
neurons can relieve motor deficits in animal models of Parkinson's disease (PD). Clinical …
neurons can relieve motor deficits in animal models of Parkinson's disease (PD). Clinical …
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
R López de Maturana, V Lang, A Zubiarrain… - Journal of …, 2016 - Springer
Background Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial
and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in …
and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in …
iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology
A Matamoros-Angles, LM Gayosso… - Molecular …, 2018 - Springer
Abstract Gerstmann-Sträussler-Scheinker (GSS) syndrome is a fatal autosomal dominant
neurodegenerative prionopathy clinically characterized by ataxia, spastic paraparesis …
neurodegenerative prionopathy clinically characterized by ataxia, spastic paraparesis …
Expansion of human midbrain floor plate progenitors from induced pluripotent stem cells increases dopaminergic neuron differentiation potential
S Fedele, G Collo, K Behr, J Bischofberger, S Müller… - Scientific reports, 2017 - nature.com
Human induced pluripotent stem cells (hiPSCs) are invaluable to study developmental
processes and disease mechanisms particularly in the brain. hiPSCs can be differentiated …
processes and disease mechanisms particularly in the brain. hiPSCs can be differentiated …
Generation of human liver organoids from pluripotent stem cell-derived hepatic endoderms
K Kulkeaw, A Tubsuwan, N Tongkrajang… - PeerJ, 2020 - peerj.com
Background The use of a personalized liver organoid derived from human-induced
pluripotent stem cells (HuiPSCs) is advancing the use of in vitro disease models for the …
pluripotent stem cells (HuiPSCs) is advancing the use of in vitro disease models for the …
Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian …
IR de Luzy, JC Niclis, CW Gantner… - Journal of …, 2019 - Soc Neuroscience
Human pluripotent stem cells (hPSCs) are a promising resource for the replacement of
degenerated ventral midbrain dopaminergic (vmDA) neurons in Parkinson's disease …
degenerated ventral midbrain dopaminergic (vmDA) neurons in Parkinson's disease …
LRRK2 expression is deregulated in fibroblasts and neurons from Parkinson patients with mutations in PINK1
G Azkona, R López de Maturana, P Del Rio… - Molecular …, 2018 - Springer
Abstract Mutations in PINK1 (PARK6), a serine/threonine kinase involved in mitochondrial
homeostasis, are associated with early onset Parkinson's disease. Fibroblasts from …
homeostasis, are associated with early onset Parkinson's disease. Fibroblasts from …