Lipids function not only as the major structural components of cell membranes, but also as
molecular messengers that transduce signals to trigger downstream signaling events in the …

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic
acid (PA). Mammalian DGK consists of ten isozymes (α–κ) and governs a wide range of …

To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …

Cholesterol and phosphatidyl inositol 4, 5-bisphosphate (PIP2) are hydrophobic molecules
that regulate protein function in the plasma membrane of all cells. In this review, we discuss …

Anionic phospholipids are minor but prominent components of the plasma membrane that
are necessary for ion channel function. Their persistence in bulk membranes, in particular …

Alcohol is a psychoactive substance that is widely used and, unfortunately, often abused. In
addition to acute effects such as intoxication, it may cause many chronic pathological …

TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with
roles in maintaining the resting membrane potential and fast action potential conduction …

Abstract TWIK related K+ channel (TREK-1) is a mechano-and anesthetic sensitive channel
that when activated attenuates pain and causes anesthesia. Recently the enzyme …

Experimental models of a clinical, pathophysiological context are used to understand
molecular mechanisms and develop novel therapies. Previous studies revealed better …

Motivations for understanding the underlying mechanisms of alcohol toxicity range from
economical to toxicological and clinical. On the one hand, acute alcohol toxicity limits biofuel …