Stress, which refers to a combination of physiological, neuroendocrine, behavioral, and
emotional responses to novel or threatening stimuli, is essentially a defensive adaptation …

Traumatic stress may chronically affect master homeostatic systems at the crossroads of
peripheral and central susceptibility pathways and lead to the biological embedment of …

In humans, exposure to early life stress (ELS) is an established risk factor for the
development of substance use disorders (SUDs) during later life. Similarly, rodents exposed …

Early-life adversity (ELA) is known to alter brain circuit maturation as well as increase
vulnerability to cognitive and emotional disorders. However, the importance of examining …

Early life stress (ELS) is considered a risk factor for the development of psychiatric
conditions, including depression and anxiety disorder. Individuals that live in adverse …

Background Few studies have investigated the associations between heavy metals and
anxiety. The purpose of this study was to examine the associations between single and …

Patients with persistent pain have sometimes history of physical abuse or neglect during
infancy. However, the pathogenic mechanisms underlying orofacial pain hypersensitivity …

Background: Psoriasis is a common chronic inflammatory skin disease that often causes
depression. Early life experience affects brain development and relates to depression …

Introduction: Disruption of maternal care using maternal separation (MS) models has
provided significant evidence of the deleterious long-term effects of early life stress. Several …

Rationale Indomethacin (INDO) is a widely utilized non-steroidal anti-inflammatory drug
(NSAID) with recognized effect on the central nervous system. Although previous reports …