Pharmacology of cardiac potassium channels
Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …
Structure and function of cardiac potassium channels
DJ Snyders - Cardiovascular research, 1999 - academic.oup.com
Recent advances in molecular biology have had a major impact on our understanding of the
biophysical and molecular properties of ion channels. This review is focused on cardiac …
biophysical and molecular properties of ion channels. This review is focused on cardiac …
Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action
BS Zhorov, DB Tikhonov - Journal of neurochemistry, 2004 - Wiley Online Library
In the last decade, the idea of common organization of certain ion channel families
exhibiting diverse physiological and pharmacological properties has received strong …
exhibiting diverse physiological and pharmacological properties has received strong …
Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem.
CH Kindler, CS Yost, AT Gray - Anesthesiology, 1999 - europepmc.org
Background Recently, a new structural family of potassium channels characterized by two
pore domains in tandem within their primary amino acid sequence was identified. These …
pore domains in tandem within their primary amino acid sequence was identified. These …
Molecular basis for Kv1. 5 channel block: conservation of drug binding sites among voltage-gated K+ channels
Kv1. 5 channels conduct the ultrarapid delayed rectifier current (I Kur) that contributes to
action potential repolarization of human atrial myocytes. Block of these channels has been …
action potential repolarization of human atrial myocytes. Block of these channels has been …
Two-pore domain potassium channels: new sites of local anesthetic action and toxicity
CH Kindler, SC Yost - Regional Anesthesia & Pain Medicine, 2005 - rapm.bmj.com
Potassium (K+) channels form the largest family of ion channels with more than 70 such
genes identified in the human genome. They are organized in 3 superfamilies according to …
genes identified in the human genome. They are organized in 3 superfamilies according to …
Interactions of anesthetics with their targets: non-specific, specific or both?
BW Urban, M Bleckwenn, M Barann - Pharmacology & therapeutics, 2006 - Elsevier
What makes a general anesthetic a general anesthetic? We shall review first what general
anesthesia is all about and which drugs are being used as anesthetics. There is neither a …
anesthesia is all about and which drugs are being used as anesthetics. There is neither a …
IKur/Kv1.5 channel blockers for the treatment of atrial fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia. Anti-arrhythmic drugs
remain the mainstay of therapy, but the available class I and III anti-arrhythmic drugs are …
remain the mainstay of therapy, but the available class I and III anti-arrhythmic drugs are …