Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Allosteric and transmembrane (TM) signaling are among the major questions of structural
biology. Here, we review and discuss signal transduction in four‐helical TM bundles …

Tumor necrosis factor receptor 1 (TNFR1) is a central mediator of the inflammatory pathway
and is associated with several autoimmune diseases such as rheumatoid arthritis. A revision …

Here, we discuss the transition model of receptor tyrosine kinase (RTK) activation, which is
derived from biophysical investigations of RTK interactions and signaling. The model …

Receptor tyrosine kinases (RTKs) are cell surface receptors which control cell growth and
differentiation, and play important roles in tumorigenesis. Despite decades of RTK research …

Tumor necrosis factor receptors (TNFR1 and TNFR2) play key roles in mediating
inflammatory response and cell death signaling, which are associated with autoimmune …

Receptor tyrosine kinases (RTKs) are single-pass membrane proteins that regulate cell
growth, differentiation, motility, and metabolism. Here, we review recent advancements in …

Inhibition of tumor necrosis factor receptor 1 (TNFR1) is a billion-dollar industry for treatment
of autoimmune and inflammatory diseases. As current therapeutics of anti-TNF leads to …

Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF
induced downstream signaling and regulating inflammatory response. Recent studies have …

Extracellular vesicles are lipid-bilayer-enclosed nanoparticles present in the majority of
biological fluids that mediate intercellular communication. EVs are able to transfer their …