By the use of a fluorogenic thrombin substrate and continuous calibration of each individual
sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in …

Thrombin is the central enzyme in the coagulation cascade. Estimation of an individual's
potential to generate thrombin may correlate more closely with a hyper‐or hypo‐coagulable …

Thrombin is a pivotal player in the coagulation system. In clotting blood a transient wave of
thrombin appears after a lag time. Clotting occurs at the start of the wave. The amount of …

Hemophilia is a bleeding disorder that afflicts about 1 in 5000 males. Treatment relies upon
replacement of the deficient factor, and response to treatment both in clinical research and …

The treatment of hemophilia consists of clotting factor replacement to prevent and control
bleeding. The development of an inhibitor is one of the most serious complications of the …

Thromboelastography (TEG) was first described by Hartert in 1948, and was designed to
monitor viscoelastic clot strength in whole blood in real time. The current TEG method and …

The thrombin generation test (TGT) has demonstrated utility in evaluating overall hemostatic
capacity both in bleeding and thrombotic disorders. Although the test is currently well …

Heparin was discovered around 1922 by Howell (Baltimore) and was further developed by
the teams of Best (Toronto) and Jorpes (Stockholm). Kakkar (London) propagated its routine …

Clinical response to bypassing agents (BPAs) may vary between patients. Surgery is a
particular situation, requiring effective hemostasis during the procedure and for several days …

Understanding the mechanism of action of normal hemostasis and how the bypassing
agents recombinant activated factor VII (rFVIIa; NovoSeven) and plasma‐derived activated …