Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …

Two of the most fascinating bacterial nanomachines—the broadly disseminated rotary
flagellum at the heart of cellular motility and the eukaryotic cell–puncturing injectisome …

Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …

Secreted bacterial type III secretion system (T3SS) proteins are essential for successful
infection by many human pathogens. Both T3SS translocator SipC and effector SipA are …

Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide
and represents a major public health concern. Over the past two decades, significant …

Many bacterial pathogens rely on virulent type III secretion systems (T3SSs) or injectisomes
to translocate effector proteins in order to establish infection. The central component of the …

Controlled release of neurotransmitters stored in synaptic vesicles (SVs) is a fundamental
process that is central to all information processing in the brain. This relies on tight coupling …

Bilayered membranes separate cells from their surroundings and form boundaries between
intracellular organelles and the cytosol. Gated transport of solutes across membranes …

Cryogenic electron tomography (cryo-ET) allows structural determination of biomolecules in
their native environment (in situ). Its potential of providing information on the dynamics of …