Comprehensive overview of carboxamide derivatives as succinate dehydrogenase inhibitors

B Luo, Y Ning - Journal of Agricultural and Food Chemistry, 2022 - ACS Publications
Up to now, a total of 24 succinate dehydrogenase inhibitors (SDHIs) fungicides have been
commercialized, and SDHIs fungicides were also one of the most active fungicides …

Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes

A Singh, D Malhotra, K Singh, R Chadha… - Journal of Molecular …, 2022 - Elsevier
Thiazole derivatives remains honored heterocycles in the field of medicinal chemistry. This
scaffold has been proven as a universal motif that is present in numerous pharmacologically …

Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm …

AY Alzahrani, YA Ammar, M Abu-Elghait, MA Salem… - Bioorganic …, 2022 - Elsevier
Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …

Novel 1, 3-thiazole analogues with potent activity against breast cancer: A design, synthesis, in vitro, and in silico study

MG Salem, DMA El-Maaty, YIM El-Deen, BH Elesawy… - Molecules, 2022 - mdpi.com
Breast cancer is the most common cancer in women, responsible for over half a million
deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen-and sulfur …

The role of five-membered heterocycles in the molecular structure of antibacterial drugs used in therapy

A Rusu, IM Moga, L Uncu, G Hancu - Pharmaceutics, 2023 - mdpi.com
Five-membered heterocycles are essential structural components in various antibacterial
drugs; the physicochemical properties of a five-membered heterocycle can play a crucial …

Comparison of the interactions of fanetizole with pepsin and trypsin: Spectroscopic and molecular docking approach

Y Yue, Q Tu, Y Guo, Y Wang, Y Xu, Y Zhang… - Journal of Molecular …, 2022 - Elsevier
In this work, the binding affinity of fanetizole with proteases pepsin and trypsin were
investigated by spectroscopy and molecular docking. As a thiazole derivative, the …

Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress

B Sharma, VJ Singh, PA Chawla - Bioorganic Chemistry, 2021 - Elsevier
Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …

New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies

DH Dawood, MM Sayed, STK Tohamy, ES Nossier - ACS omega, 2023 - ACS Publications
The antibiotic resistance problems constitute a considerable threat to human health
worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an …

Spectroscopic (UV–vis, FT-IR, FT-Raman, and NMR) analysis, structural benchmarking, molecular properties, and the in-silico cerebral anti-ischemic activity of 2 …

W Emori, GJ Ogunwale, H Louis, EC Agwamba… - Journal of Molecular …, 2022 - Elsevier
Considering the tremendous application of benzothiazole and its analogs in medicinal
chemistry, 2-amino-6-ethoxybenzothiazole (AEB) was selected to extensively investigate its …

Synthesis and characterization of two new mixed‐ligand Cu (II) complexes of a tridentate NN'O type Schiff base ligand and N‐donor heterocyclic co‐ligands: In vitro …

L Ghasemi, M Behzad, A Khaleghian… - Applied …, 2022 - Wiley Online Library
Two new mixed‐ligand complexes with general formula [Cu (SB)(L')] ClO4 (1 and 2) were
synthesized and characterized by different spectroscopic and analytical techniques …