The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters
family found in humans. These proteins actively transport endogenous and exogenous …

The term “pharmacogenetics” is used to describe the study of variability in drug response
due to heredity. It is associated with “gene–drug interactions”. Later on, the term …

Cisplatin (CDDP) is a highly effective antineoplastic agent, widely used in the treatment of
various malignant tumors. However, its major problems are side effects associated to …

Abstract Background Interleukin‐1β (IL‐1B) has been recognized as a pro‐inflammatory
cytokine and associated with tumorigenesis. We aimed to evaluate the contribution of IL‐1B …

During the 3rd congress of the European Society of Pharmacogenomics and Personalised
Therapy (ESPT) in Budapest in 2015, a preliminary meeting was held aimed at establishing …

Abstract Background Topoisomerase 2‐alpha (TOP2A) is an enzyme that controls topologic
changes in DNA during transcription and replication. ERCC1 is an enzyme that takes part in …

Although platinum-based chemotherapy remains the standard treatment for advanced
NSCLC patients, clinical outcomes are poor and most patients develop high-grade toxicities …

Chemotherapy based on platinum compounds is the standard treatment for NSCLC patients
with EGFR wild type, and is also used as second line in mutated EGFR patients …

Genetic variations in genes involved in repairing platinum‐induced DNA lesions may
contribute to the toxicity of platinum‐based chemotherapy. The role of single‐nucleotide …

Background Surgery is the standard treatment for early-stage NSCLC, and platinum-based
chemotherapy remains as the treatment of choice for advanced-stage NSCLC patients with …