Hyperhomocysteinemia/Homocysteinuria is characterized by an increased level of toxic
homocysteine in the plasma. The plasma concentration of homocysteine is 5–15 μmol/L in …

A high level of homocysteine (Hcy) is associated with oxidative/ER stress, apoptosis, and
impairment of angiogenesis, whereas hydrogen sulfide (H2S) has been found to reverse this …

Cancer cells selectively take up exogenous serine or synthesize serine via the serine
synthesis pathway for conversion into intracellular glycine and one‐carbon units for …

Background: Intakes of choline and betaine have been inversely related to the risk of various
neoplasms, but scant data exist on nasopharyngeal carcinoma (NPC). We examined the …

Background Non-small cell lung cancer (NSCLC) accounts for about 85% of all types of lung
cancer. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is involved in DNA …

Neural tube defects (NTDs) are congenital abnormalities in the central nervous system. The
exact etiology of NTDs is still not determined, but several genetic and epigenetic factors …

Objectives Neural tube defect (NTD) is a common disease among neonates with multiplex
symptom and complex origins, and the exact mechanism of NTD has not been definitely …

Betaine homocysteine methyltransferase (BHMT) catalyzes the synthesis of methionine
using betaine and homocysteine (Hcy), which is restricted to the liver and kidney. Impaired …

Background Studies investigating the association between single-nucleotide polymorphisms
(SNPs) of the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and cancer risk report …

Down syndrome (DS) is the most common form of mental retardation of genetic etiology.
Several polymorphisms in genes involved with the folic acid cycle have been associated to …