Molecular networks in Network Medicine: Development and applications
EK Silverman, HHHW Schmidt… - … Systems Biology and …, 2020 - Wiley Online Library
Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
Statistical and integrative system-level analysis of DNA methylation data
AE Teschendorff, CL Relton - Nature Reviews Genetics, 2018 - nature.com
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
[HTML][HTML] The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery
HG Stunnenberg, S Abrignani, D Adams, M de Almeida… - Cell, 2016 - cell.com
The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …
catalog of high-resolution reference epigenomes of major primary human cell types. The …
[HTML][HTML] Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling
DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
Iterative random forests to discover predictive and stable high-order interactions
Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes,
genome-wide binding sites for proteins, and many other molecular processes. However …
genome-wide binding sites for proteins, and many other molecular processes. However …
Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …
patterns that may be related to psychiatric risk. However, few studies have investigated …
[HTML][HTML] Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian …
Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …
the general population remains uncertain. Methods and Findings We conducted an …
Computational deconvolution of transcriptomics data from mixed cell populations
Gene expression analyses of bulk tissues often ignore cell type composition as an important
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …
Identification of differentially methylated cell types in epigenome-wide association studies
An outstanding challenge of epigenome-wide association studies (EWASs) performed in
complex tissues is the identification of the specific cell type (s) responsible for the observed …
complex tissues is the identification of the specific cell type (s) responsible for the observed …