Correlation AnalyzeR: functional predictions from gene co-expression correlations
HE Miller, AJR Bishop - BMC bioinformatics, 2021 - Springer
Background Co-expression correlations provide the ability to predict gene functionality
within specific biological contexts, such as different tissue and disease conditions. However …
within specific biological contexts, such as different tissue and disease conditions. However …
[HTML][HTML] Targeting the Wnt/β-catenin pathway in human osteosarcoma cells
F Fang, A VanCleave, R Helmuth, H Torres, K Rickel… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Aberrant activation of Wnt signaling has been implicated in human osteosarcoma, which
may provide a genetic vulnerability that can be targeted in osteosarcoma treatment. To test …
may provide a genetic vulnerability that can be targeted in osteosarcoma treatment. To test …
DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma
M Barenboim, M Kovac, B Ameline… - PLoS Computational …, 2021 - journals.plos.org
Although osteosarcoma (OS) is a rare cancer, it is the most common primary malignant bone
tumor in children and adolescents. BRCAness is a phenotypical trait in tumors with a defect …
tumor in children and adolescents. BRCAness is a phenotypical trait in tumors with a defect …
Unraveling the chaotic genomic landscape of primary and metastatic canine appendicular osteosarcoma with current sequencing technologies and bioinformatic …
Osteosarcoma is a rare disease in children but is one of the most common cancers in adult
large breed dogs. The mutational landscape of both the primary and pulmonary metastatic …
large breed dogs. The mutational landscape of both the primary and pulmonary metastatic …
A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma
V Rey, J Tornín, JJ Alba-Linares, C Robledo… - …, 2024 - thelancet.com
Background Sarcomas represent an extensive group of malignant diseases affecting
mesodermal tissues. Among sarcomas, the clinical management of chondrosarcomas …
mesodermal tissues. Among sarcomas, the clinical management of chondrosarcomas …
KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling.
L Zhang, P Yang, Q Liu, J Wang, F Yan, L Duan… - …, 2020 - search.ebscohost.com
Krüppel-like factor 8 (KLF8) regulates critical gene transcription associated with different
types of cancer. A novel paradigm in tumor biology suggests that the initiation and …
types of cancer. A novel paradigm in tumor biology suggests that the initiation and …
[HTML][HTML] Bioinformatics analysis and validation of mesenchymal stem cells related gene MT1G in osteosarcoma
S Zheng, X Cheng, S Ke, L Zhang, H Wu, D He… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Background: Osteosarcoma (OS) is a primary malignant bone tumor arising from
mesenchymal cells. The standard clinical treatment for OS involves extensive tumor …
mesenchymal cells. The standard clinical treatment for OS involves extensive tumor …
[HTML][HTML] The long non-coding RNA PARTICLE is associated with WWOX and the absence of FRA16D breakage in osteosarcoma patients
VB O'Leary, D Maugg, J Smida, D Baumhoer… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Breakage of the fragile site FRA16D disrupts the WWOX (WW Domain Containing
Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of …
Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of …
Genetics of congenital solid tumors
MC Jurcă, ME Ivaşcu, AA Jurcă… - … of Morphology and …, 2021 - pmc.ncbi.nlm.nih.gov
When we discuss the genetics of tumors, we cannot fail to remember that in the second
decade of the twentieth century, more precisely in 1914, Theodore Boveri defined for the first …
decade of the twentieth century, more precisely in 1914, Theodore Boveri defined for the first …
Biology of Osteosarcomas
M Serra, CM Hattinger - Diagnosis of Musculoskeletal Tumors and Tumor …, 2020 - Springer
Unlike other sarcomas, high-grade osteosarcoma (HGOS) is characterized by complex,
unbalanced karyotypes and alterations in multiple genes and pathways. Due to HGOS high …
unbalanced karyotypes and alterations in multiple genes and pathways. Due to HGOS high …