The Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) approach has been
widely applied as an efficient and reliable free energy simulation method to model molecular …

Glycogen synthase kinase-3β (GSK3β) is a pivotal protein kinase implicated in a spectrum of
debilitating diseases, encompassing cancer, diabetes, and neurodegenerative disorders …

Alzheimer's disease (AD) belongs to the most common forms of dementia that causes a
progressive loss of brain cells and leads to memory impairment and decline of other thinking …

Tumors are still one of the main causes of death; therefore, the search for new therapeutic
agents that will enable the implementation of effective treatment is a significant challenge for …

The global impact of Alzheimer's disease (AD) necessitates intensive research to find
appropriate and effective drugs. Many studies in AD suggested beta-amyloid plaques and …

Abstract Context N 6-adenosine-methyltransferase (METTL3) is the catalytic domain of the
'writer'proteins which is involved in the post modifications of N 6-methyladinosine (m 6 A) …

Gamma-aminobutyric acid (GABA) signaling is the principal inhibitory pathway in the central
nervous system. It is critical in neuronal cell proliferation and fate determination. Any …

Emerging as a promising drug target for Alzheimer's disease (AD) therapy, glycogen
synthase kinase 3β (GSK-3β) has garnered attention. This study sought to rigorously …

A good understanding of the inhibition mechanism of enzymes exhibiting high levels of
similarity is the first step to the discovery of new drugs with selective potential. Examples of …

Abstract Methyltransferase‐like 3 (METTL3) serves as a primary catalytic enzyme within the
N6‐methyladenosine (m6 A) methyltransferase system, playing a crucial role in various …