The discovery of the first gene associated with hereditary breast cancer, BRCA1, was
anticipated to greatly increase our understanding of both hereditary and sporadic forms of …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

An Erratum has been published for this article in Statistics in Medicine 2005; 24 (1): 156.
Please note that the corresponding author's e‐mail address has now changed. For further …

Background Women with extensive dense breast tissue visible on a mammogram have a
risk of breast cancer that is 1.8 to 6.0 times that of women of the same age with little or no …

The knowledge of human genetic variation that will come from the human genome
sequence makes feasible a polygenic approach to disease prevention, in which it will be …

The past decade has seen great strides in our understanding of the genetic basis of human
disease. Arguably, the most profound impact has been in the area of cancer genetics, where …

The generalized estimating equation (GEE) approach is a widely used statistical method in
the analysis of longitudinal data in clinical and epidemiological studies. It is an extension of …

In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic
counselling purposes, it is important to allow for the fact that other breast cancer …

Oncology indispensably leads us to personalized medicine, which allows an individual
approach to be taken with each patient. Personalized oncology is based on …