Starting with cholesterol homeostasis, the first part of the review addresses various aspects
of cholesterol metabolism in neuronal and glial cells and the mutual crosstalk between the …

Statins are among the most widely used drug classes in the world. Apart from their basic
mechanism of action, which is lowering cholesterol levels, many pleiotropic effects have …

Objective: Statins lower cardiovascular event risk, yet, they paradoxically increase coronary
artery calcification, a marker consistently associated with increased cardiovascular risks. As …

Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and
are the cornerstone of lipid-lowering treatment. They significantly reduce cardiovascular …

Statins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting
cholesterol synthesis. These effects are primarily beneficial for the patient's vascular system …

OBJECTIVE: Recent evidence suggests that statins, among lipid-lowering drugs, can be
used to lower serum cholesterol levels for reducing the risk of cardiovascular disease in …

Depression has a large burden, but the development of new drugs for its treatment has
proved difficult. Progresses in neuroscience have highlighted several physiopathological …

Заключение. Различное сочетание предикторов, отражающее патогенез развития
перипроцедурного ОПМ, определяет величину этого острого осложнения плановых …

Purpose Statins have cardiovascular protective effects in addition to lipid-lowering effects.
However, no human studies have examined whether statins prevent aortic dissection. This …

Degeneration of medial layer of elastic arteries with deposition of collagen is termed arterial
stiffness, and considered as a risk factor of cardiovascular events. Several mechanisms are …