Weil's Disease—Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota

P Petakh, V Isevych, A Kamyshnyi, V Oksenych - Biomolecules, 2022 - mdpi.com
Leptospirosis is an important zoonotic disease, causing about 60,000 deaths annually. In
this review, we have described in detail the immunopathogenesis of leptospirosis, the …

Leptospiral immunoglobulin-like domain proteins: Roles in virulence and immunity

DA Haake, J Matsunaga - Frontiers in Immunology, 2021 - frontiersin.org
The virulence mechanisms required for infection and evasion of immunity by pathogenic
Leptospira species remain poorly understood. A number of L. interrogans surface proteins …

ErpY-like Protein Interaction with Host Thrombin and Fibrinogen Intervenes the Plasma Coagulation through Extrinsic and Intrinsic Pathways

S Hota, M Kumar - ACS Infectious Diseases, 2024 - ACS Publications
The survival and proliferation of pathogenic Leptospira within a host are complex
phenomena that require careful consideration. The ErpY-like lipoprotein, found on the outer …

Binding of human plasminogen by the lipoprotein LipL46 of Leptospira interrogans

JV Santos, PRM Pereira, LGV Fernandes… - Molecular and cellular …, 2018 - Elsevier
Leptospirosis is a widespread zoonosis caused by pathogenic Leptospira. Bacteria
disseminate via the bloodstream and colonize the renal tubules of reservoir hosts …

[PDF][PDF] Binding of human plasminogen and high-molecular-mass kininogen by cell surface-exposed proteins of Candida parapsilosis

J Karkowska-Kuleta, D Zajac, G Bras… - Acta Biochimica …, 2017 - frontierspartnerships.org
The development of infections caused by pathogenic microorganisms affects the action of
major systems involved in maintaining the biochemical homeostasis of the human organism …

Тренды современного лептоспироза

ВН Городин, ДЛ Мойсова, ВА Бахтина… - Эпидемиология и …, 2018 - cyberleninka.ru
Представлен обзор литературы, посвященный одному из наиболее
распространённых и клинически значимых зоонозов лептоспирозу. В статье …

[HTML][HTML] Protection against leptospirosis conferred by Mycobacterium bovis BCG expressing antigens from Leptospira interrogans

J Dorneles, AB Madruga, ACPS Neto, C Rizzi… - Vaccine, 2020 - Elsevier
Leptospirosis is a zoonotic disease worldwide and caused by the pathogenic spirochetes of
the genus Leptospira. Bacterins make up the vaccines used against leptospirosis, but they …

Role of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its …

KK Ghosh, A Prakash, A Dhara, MS Hussain… - Infection and …, 2019 - Am Soc Microbiol
Leptospirosis is one of the most widespread zoonoses caused by pathogenic Leptospira
spp. In this study, we report that the LIC11966/ErpY-like lipoprotein is a surface-exposed …

Virulent Leptospira interrogans Induce Cytotoxic Effects in Human Platelets in vitro Through Direct Interactions

ML Vieira, ALTO Nascimento - Frontiers in Microbiology, 2020 - frontiersin.org
Leptospirosis is a prevalent zoonotic disease, caused by bacteria of the genus Leptospira.
Leptospirosis frequently leads to hemostatic disturbances, and the severe cases are marked …

The interplay between host haemostatic systems and Leptospira spp. infections

ML Vieira, H Herwald… - Critical reviews in …, 2020 - Taylor & Francis
Hemostasis is a defence mechanism that protects the integrity of the vascular system and is
comprised of the coagulation cascade, fibrinolysis, platelet aggregation, and vascular …